The project

The team involved in the project has a long-lasting expertise in the development of nanoparticle systems for pharmaceutical applications.
From this skill, the idea of exploiting the ability of some natural substances present in the grapes to transform silver salts into silver nanoparticles (AgNP) is born. Such idea will take advantage from the rich possibilities offered by the many types of grapes traditionally grown on the territory of Pavia.

The AgNP will be produced by means of a “green” synthesis (without the use of harmful chemicals) that is respectful of the environment and cheap, since waste from wine production will be used.

It is known that grape and its derived products are rich in substances such as polyphenols, which have antimicrobial, anti-inflammatory, antioxidant and derma-protective properties. These substances will cover the AgNPs, whose excellent antibacterial properties, also effective against antibiotic-resistant strains, are well known.

The very small size of the nanosystems would allow a rapid entry into bacteria, while the natural substances that coat them would improve the compatibility with the cells of our body and enhance the healing of skin lesions, acting in synergy with antibacterial properties, typical of silver.

The nanoparticles will then be loaded into “smart” dressings based on natural polymers, capable of mimicking the structure of the skin layers and delivering the active substances in a controlled way, according to the therapeutic needs.

Since shape and size of nanomaterials affect their properties, an important part of the research will be devoted to the rational study of how the conditions of synthesis (e.g. type of waste and/or extract, grape quality, temperature and concentration of the reagents) influence these properties, and, in turn, the therapeutic efficacy of the developed products.

What we offer is a mix of tradition (the countryside, the culture of wine), of “non- dangerous” chemistry and of ecology with a look at the present – the research – and at the immediate future – its application. Chemistry leaves the academic laboratories to meet the reality of the territory.


Links:

Inorganic Nanochemistry Lab: http://www-5.unipv.it/inlab/

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Goals

First goal 12.500 euro

Six months grant for a young researcher

Second goal 25.000 euro

One year grant for a young researcher

Third goal 50.000 euro

Two grants of one year for two young researchers

Sponsor

Montelio Wines

Azienda Agricola Montelio

Enocuriosi

Associazione culturale

Griffini

Pasticceria Griffini

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Rewards

Donation of 20 €

Shopper with Logo

Donation of 50 €

Shopper con Logo + membership year 2019 for association “Enocuriosi”

Donation of 200 €

Membership year 2019 for association “Enocuriosi” + fine wine bottle

Donation of 500 €

Membership year 2019 for association “Enocuriosi” + acknowledgments in scientific publications generated within the project, with an electronic copy of the publication.

Team

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Angelo Maria Taglietti

| Founder

Angelo Maria Taglietti

| Founder
Associate Professor - Team leader
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Silvia Rossi

| Founder

Silvia Rossi

| Founder
Professor, supervisor
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Piersandro Pallavicini

Piersandro Pallavicini

Full Professor – Responsable for Nanomaterials Synthesis
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Pietro Grisoli

Pietro Grisoli

Assistant Professor - Responsable for in vitro evaluation of antimicrobial activity of developed products
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Giacomo Dacarro

Giacomo Dacarro

Assistant Professor - Nanomaterials Synthesis
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Agnese D’Agostino

Agnese D’Agostino

Post-Doc - Nanomaterials Synthesis
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Barbara Vigani

Barbara Vigani

Post-Doc - Responsable for in vitro evaluation of wound healing activity of developed products
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Backers

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  5. Anonymous
  6. Evento "Una Piotta d'argento" 2 giugno
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  • Tessera anno 2019 associazione “Enocuriosi” + bottiglia di vino pregiato

  • Tessera anno 2019 associazione “Enocuriosi” + Ringraziamento nelle pubblicazioni scientifiche prodotte nell’ambito del progetto, invio di una copia elettronica delle pubblicazioni stesse

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