The project
Monday November 24th, 2014

Because of the spread of M. tuberculosis strains multi-resistant to the drugs currently used in therapy, there is the need to have a higher number of molecules in the stages of pre-clinical and clinical development. The purpose of this project is to search for new compounds with anti-tuberculosis activity and to study their mechanisms of action and resistance. In our laboratory, we have identified the cellular target of a class of new anti-TB drugs, the benzothiazinones (BTZ). The target of BTZ is DprE1, an enzyme involved in cell wall biosynthesis, present only in bacterial cells. This drug is now in the final stage of pre-clinical development and will enter the clinical trials the next autumn.

New compounds will be tested against M. tuberculosis and the most effective ones will be selected for further analysis. More precisely, the funds raised through this campaign will be used to identify the target of a new drug, just found out and very active against multidrug-resistant strains. Finding the target means to know the mechanism of action of the drug, that is where it hits the molecule in the cell. Once identified, we can also improve the molecule and make it even more efficient.

Tuberculosis is a disease strongly increasing also due to the globalization effect, the easiness of individuals to travel the world and migration, which involves the arrival of people from areas of high tuberculosis endemicity. In addition, a recent study by the World Health Organization launched an alarming warning on antibiotic resistance: “Minor infections are likely to return to kill.” Among the infections most at risk WHO includes tuberculosis.

 

LINK

The achieved results regarding benzothiazinones have been published in SCIENCE and the article has been cited as one of the “key papers” published in 2009 (see: Nature Medicines 15:1349)
Stop TB italia
Advisory board component of : innovative medicines for tuberculosis

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"Tuberculosis: science interacts with the music" to be held soon at theCinema teatro Politeama (Corso Cavour 20, Pavia).

For donations exceeding 500 euros, the donor's name will be mentioned in the publication regarding the achieved results.

Team

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Giovanna Riccardi

Full Professor of Microbiology and Head of the Laboratory of Molecular Microbiology, Department of Biology and Biotechnology, University of Pavia | Founder

Giovanna Riccardi

Full Professor of Microbiology and Head of the Laboratory of Molecular Microbiology, Department of Biology and Biotechnology, University of Pavia | Founder
Full Professor of Microbiology and Head of the Laboratory of Molecular Microbiology, Department of Biology and Biotechnology, University of Pavia. She was the holder of several national and international research projects, primarily associated with the issue of tuberculosis and the search for new drugs to fight it. She is currently part of the Steering Committee of the project funded by the European Commission: More Medicines for tuberculosis. She has several international collaborations. She is author of: 91 papers in international journals with referees, 4 chapters of the book, several communications to national and international conferences and two patents.
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Edda De Rossi

Associate Professor of Microbiology in the Department of Biology and Biotechnology, University of Pavia

Edda De Rossi

Associate Professor of Microbiology in the Department of Biology and Biotechnology, University of Pavia
is Associate Professor of Microbiology in the Department of Biology and Biotechnology, University of Pavia. Her research focuses in the field of tuberculosis. She is author of: 41 papers in international journals with referees and several communications in national and international conferences.
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Maria Rosalia Pasca

Researcher of Microbiology in the Department of Biology and Biotechnology, University of Pavia

Maria Rosalia Pasca

Researcher of Microbiology in the Department of Biology and Biotechnology, University of Pavia
is Researcher of Microbiology in the Department of Biology and Biotechnology, University of Pavia. She mainly studies the mechanisms of action of new drugs used against tuberculosis. She is author of: 39 papers in international journals with referees, 4 chapters of the book, several communications to national and international conferences and two patents.
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Laurent Roberto Chiarelli

Post-DOC researcher in the Department of Biology and Biotechnology, University of Pavia

Laurent Roberto Chiarelli

Post-DOC researcher in the Department of Biology and Biotechnology, University of Pavia
is a post-DOC researcher in the Department of Biology and Biotechnology, University of Pavia. He studies the mechanisms of action of antitubercular drugs from the biochemical point of view. He is an added value to the group for his formation in biochemistry. He is author of: 35 papers in international journals with referees, several communications in national and international.
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Giorgia Mori

PhD student in Biomolecular Sciences and Biotechnology at the third year, Department of Biology and Biotechnology, University of Pavia

Giorgia Mori

PhD student in Biomolecular Sciences and Biotechnology at the third year, Department of Biology and Biotechnology, University of Pavia
is a PhD student in Biomolecular Sciences and Biotechnology at the third year, Department of Biology and Biotechnology, University of Pavia. She has always worked in the characterization of the mechanisms of action of new anti-tuberculosis drugs. She is author of: 4 papers in international journals with referees, some communications in national meetings.
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Marta Esposito

PhD students in Genetics, Molecular and Cellular Biology, at the Department of Biology and Biotechnology, University of Pavia

Marta Esposito

PhD students in Genetics, Molecular and Cellular Biology, at the Department of Biology and Biotechnology, University of Pavia
is PhD students in Genetics, Molecular and Cellular Biology, at the Department of Biology and Biotechnology, University of Pavia at the beginning with the study of tuberculosis.
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Beatrice Silvia Orena

PhD students in Genetics, Molecular and Cellular Biology, at the Department of Biology and Biotechnology, University of Pavia

Beatrice Silvia Orena

PhD students in Genetics, Molecular and Cellular Biology, at the Department of Biology and Biotechnology, University of Pavia
is PhD students in Genetics, Molecular and Cellular Biology, at the Department of Biology and Biotechnology, University of Pavia at the beginning with the study of tuberculosis.

Backers

  1. Ambra Redaelli
  2. Off.Mecc Artimec CR7
  3. ATC (Italia) SRL CR7
  4. Luisa e Corrado Buroni
  5. francesco caracciolo
  6. Sandro Matteucci Anna Piccolo
  7. Paola Ceretti
  8. Novaria Services SRL
  9. Gallo Tessile
  10. FAE Project SRL CR7
  11. OROGRAF SRL CR7
  12. Associazione Fatti Per Cambiar
  13. Farmacia Fapa di Marco Branca
  14. Luigi Martinelli
  15. Sorelle Ramonda
  16. Anonymous
  17. BRUSTIA-ALFAMECCANICA
  18. Cosmolab CR7
  19. Anonymous
  20. Franco Bagnasco
  21. Ciavanni Raffaele
  22. Anonimo
  23. TBC e Musica
  24. Sonia Verzè
  25. Iro Suraci
  26. Caffè dell'Abate CR7
  27. Pietro Brandolini
  28. Gianna Muffatti
  29. Franca Bruzza
  30. Bruna Scarabelli Alberto Contini
  31. Fiorenzo Pastoni
  32. Tinteri Francesca Rosa Fedrighelli
  33. Lions Le Vigne
  34. Anonymous
  35. Roberto Bottinelli
  36. Ornella Semino
  37. Pietro Brandolini
  38. Peroni Renzo Losi Pasqualina
  39. Farmacia Di Delebio
  40. Alessandro Coda
  41. NIcoletta Orifici
  42. Ilaria Giglio
  43. Luisa Lombardi
  44. Marco Lodola
  45. Tommaso Mastropietro
  46. Sonia Mazzola
  47. Bombardieri Orietta e Graziano
  48. De Jesus Lopes Ribeiro Ana Lui
  49. Pattarini Federico Rampini Ant
  50. Marco Bellinzoni
  51. daniela russo
  52. Cristina Parolin
  53. Tiziana Loi
  54. Gabriella Campadelli
  55. Nadia Lanetti
  56. Confindustria Pavia
  57. Scharlab Italia
  58. Nicoletta Arancio
  59. Jessica Mantovani
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  66. Anonymous
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  70. Anonymous
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  72. Anonymous
  73. Maria Gravagna
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  75. Margherita Canu
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  77. Alessandra Roggeri
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  81. Carolina Muscas
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  97. Maria Rosalia Pasca
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  102. Cappelletti Arturo Di Paolo
  103. Francesco d'Aleo
  104. Alberto Cocco
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  106. Michele Gallotti
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  124. Matteo Scarabelli
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  128. Laura Riccardi
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  137. Sentinel Ch
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  175. Stefania Malvani
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  177. Carmela Giordano
  178. Laura Peroni
  179. Cristina Gyppaz
  180. Beatrice Nicolini
  181. Greta Severino
  182. Carla Tribioli
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  184. Anonymous
  185. serena albertazzi
  186. Riccardo Manganelli
  187. Antonio Rausa
  188. Anonymous
  189. ALESSIO FERRETTO
  190. Guglielmina Nadia Ranzani
  191. Giovanni Maga
  192. Anonymous
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  198. Claudio Griffini
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  210. marial piredda
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  215. Riccardo Baratto
  216. Gherard Batisti Biffignandi
  217. Laura Passera
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  224. deborah setola
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  230. Luca Valetti
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  233. Gloria Zaninetti
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  235. Carluccio Gatti
  236. Claudia Tamburnotti
  237. Maria Cristiana Papaleo
  238. Valentina La Rosa
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  240. marta sempio
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  243. Michele Porcari
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  • Have a place reserved for the show entitled "Tuberculosis: science interacts with the music"

  • The donor's name will be mentioned in the publication regarding the achieved results