Funding Successful. This project reached its goal before 18/01/2018.

The project

There are people with a higher risk of developing respiratory diseases, among which the most important and common is the emphysema. These can result of respiratory infections and inhalation of irritating substances, especially cigarette smoking. The underlying genetic defect of the increased susceptibility is the alpha1-antitrypsin deficiency, one of the most common hereditary diseases although under-diagnosed because not well known.

Is there a protective gene that defends the lungs? Is it possible to know if you have an increased risk of developing respiratory diseases, or if our own children have it before symptom appearance? This knowledge could induce virtuous behaviors such as cessation of cigarette smoke or the switch to electronic cigarettes which may be a less dangerous alternative.

The answer is YES, and it’s easy! Since some years we have developed a method for diagnosing Alfa1-antitrypsin deficiency, which is based on a kit consisting of a special filter paper, on which six drops of blood are placed. Everything can be sent as a postcard to the “Center for Diagnose and Coordination of the Inherited Alpha-1-Antitrypsin Deficiency Registry”, at the San Matteo Hospital that is the reference center for Italy. The blood drops are sufficient to perform all the biochemical and genetic tests needed for a complete and accurate diagnosis of Alfa1-antitrypsin deficiency.

Our research team is not just concerned about diagnosing but also about identifying new genetic variants which are associated with respiratory (but also hepatic) diseases. These rare variants help us in understanding which regions of the gene regulate the conformational state of Alpha-1-antitrypsin protein. In the framework of the initiative launched by the European Commission and called “European Reference Networks” (ERN) for complex or rare diseases that require highly specialized treatment and concentrated knowledge and resources, we have been identified as the reference laboratory for Western Europe.

We currently carry out more than a thousand of testing per year, thanks to state-of-the-art tools and dedication of our staff that is precarious. However, we have the ambition and certainty that we can do more. First, it is necessary to increase the awareness about the existence of this inherited risk factor and intensify the efforts against cigarette smoking. In addition, a continuous technological upgrade is necessary and it is crucial to offer future certainty and prospects to those who work on this project.

Support us!


Enter your pledge amount

  • Donazione minima

  • Spilla Alpha

  • Maglietta “Respiriamo la vita” e Spilla Alpha

  • Spilla Alpha, Maglietta “Respiriamo la vita” e Ringraziamento personale in una pubblicazione internazionale

Would you like to donate by bank transfer? click here

Would you like to donate more then 1600€ click here


Initial goal

10.000€ for a new automatic extractor for DNA/RNA

Final goal

20.000€ for support an accademic position as researcher

Further funding will support the purchase of a Next Generation Sequencer (NGS)


Media Gallery


The donor will have his name/logo on website and on social networks

Donation 20 euros

Alpha pin

Donation 250 euros

“Breath for life” t-shirt and Alpha pin

Donation 1000 euros

Alpha pin, “Breath for life” t-shirt and acknowledgement in a paper published in an International Journal.


Visualizza CV

Angelo G. Corsico

Prof. | Founder

Angelo G. Corsico

Prof. | Founder
Associate Professor in Respiratory Diseases of the Department of Internal Medicine and Therapeutic, University of Pavia Complete CV
Visualizza CV

Ilaria Ferrarotti


Ilaria Ferrarotti

Temporary Research Associate, University of Pavia Complete CV
Visualizza CV

Stefania Ottaviani


Stefania Ottaviani

Fellowship at Lab of Genetics and Biochemistry of Respiratory Diseases, IRCCS Policlinico S. Matteo Foundation, Pavia Complete CV
Visualizza CV

Michele Zorzetto


Michele Zorzetto


Coordinator of Laboratory of Biochemistry and Genetic, Policlinico San Matteo, Pavia

Complete CV


  1. Associazione Nazionale Alfa 1
  2. Anonymous
  3. Anonymous
  4. Anonymous
  5. Anonymous
  6. Anonymous
  7. Lega Italiana Fibrosi Cistica
  8. Evento Mastroianni
  9. Bismarck Brambilla
  10. Stefania Del Plato
  11. Gianfranco Pavesi Daniela Pozzi
  12. Paolo Canale
  13. Livio ed Emanuela Mura
  14. Emiliana Bonera
  15. Riccardo Pascal Lucia Fenoillet
  16. Gianfranco Pavesi Daniela Pozzi
  18. Anonymous
  19. Anonymous
  20. Anonymous
  21. Anonymous
  22. Anonymous
  23. Anonymous
  24. Anonymous
  25. Anonymous
  26. Anonymous
  27. Anonymous
  28. Pamela Baucero
  29. Anonymous
  30. Anonymous
  31. Anonymous
  32. Anonymous
  33. Anonymous
  34. Anonymous
  35. Anonymous
Show All


Do you want to know more? Contact the Research Leader!

Your Name (required)

Your Email (required)


Your Message

I accept the terms and privacy policy.

This Campaign has ended. No more pledges can be made.

  • Donazione minima

  • Spilla Alpha

  • Maglietta “Respiriamo la vita” e Spilla Alpha

  • Spilla Alpha, Maglietta “Respiriamo la vita” e Ringraziamento personale in una pubblicazione internazionale