The project

Neurodegenerative diseases affect the nervous system by inducing degeneration and death of specific neurons, such as cerebral neurons in Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and spinal motor neurons in Amyotrophic Lateral Sclerosis (ALS).

Nowadays, there is no cure for most of these pathologies. A therapeutic hope for the treatment of neurodegenerative diseases comes from regenerative medicine which holds the promise of protecting and repairing impaired organs and tissues using stem cells. To this end, stem cells need to be differentiated into the neurons that selectively die in the different pathologies. Stem cells-derived neurons have then to be transplanted into the patients nervous system, with the aim of rescuing the normal function of neural circuits.

However, stem cells-derived neurons are not yet ready to be used for the clinical studies in the field of neurodegenerative diseases. Nevertheless, there are promising results from preclinical studies, especially for Parkinson’s disease. Before the beginning of clinical experimentation, it is essential to continue and extend the preclinical studies. The first goal to reach is to set up experimental protocols to generate from stem cells the specific neurons that die in each specific disease.

In our lab, we perform basic and preclinical physiological research to assess the correct functionality of stem cells-derived neurons. Investigating the functionality of this cells and their ability to survive the transplantation and to rescue the damaged circuits is essential to understanding the mechanism underlying the recovery or the therapeutic failure.


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Goals

1° goal: 20000

scholarship (1 year) for a young researcher

2° goal: 30000

purchase of lamp and equipment for optogenetics

3° goal: 50000

extension of the scholarship for the second year

4° goal: 70000

extension of the scholarship for the third year

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GUIDED TOUR OF THE “GOLGI” UNIVERSITY MUSEUM.

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GUIDED TOUR OF THE “GOLGI” UNIVERSITY MUSEUM AND TO OUR LABORATORIES OF GENERAL PHYSIOLOGY.

DONATION 2000 EURO

WHEN FEASIBLE, ACKNOWLEDGMENT IN THE PAPERS REGARDING THE PROJECT AND E-MAILING OF AN ELECTRONIC COPY OF THE PAPERS.

Team

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Gerardo Biella

Prof. | Founder

Gerardo Biella

Prof. | Founder
Associate Professor, University of Pavia Complete CV
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Mauro Toselli

Prof. | Founder

Mauro Toselli

Prof. | Founder
Full Professor of Physiology, University of Pavia
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Francesca Talpo

Dott.

Francesca Talpo

Dott.
Post Doctoral Assistant, University of Pavia
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Claudia Maniezzi

Dott.

Claudia Maniezzi

Dott.
Post Doctoral Assistant, Department of Biosciences, University of Pavia Complete CV
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Elisabetta Cesana

Dott.

Elisabetta Cesana

Dott.
Collaborator, University of Pavia Complete CV
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Michela Cristofolini

Studente

Michela Cristofolini

Studente
Master's Internship, University of Pavia Complete CV
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Giuseppe Balsamo

Studente

Giuseppe Balsamo

Studente
Internship at the Laboratory of Biophysics and Physiology of Cortical Neurons Complete CV
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Simona Manzella

Studente

Simona Manzella

Studente

Internship in neuroscience, electrophysiology, University of Pavia

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Jessica Palmieri

Studente

Jessica Palmieri

Studente
Master's Internship, University of Pavia Complete CV
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Carmen De Giorgi

Carmen De Giorgi

External collaborator
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Contribute
  • Donazione minima

  • 2 INGRESSI OMAGGIO PER EVENTO DI CHIUSURA DELLA CAMPAGNA (SPETTACOLO TEATRALE). Note: per l’ingresso omaggio, presentarsi il giorno dello spettacolo fornendo nominativo

  • VISITA GUIDATA AL MUSEO GOLGI DELL’UNIVERSITA’

  • VISITA GUIDATA AL MUSEO GOLGI DELL’UNIVERSITA’ E AI LABORATORI DI RICERCA DI FISIOLOGIA GENERALE

  • RINGRAZIAMENTO NELLE PUBBLICAZIONI SCIENTIFICHE RELATIVE AL PROGETTO E INVIO DI UNA COPIA ELETTRONICA DELLE PUBBLICAZIONI STESSE

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