Funding Successful. This project reached its goal before 31/07/2019.

The project

In recent years, the Laboratory of Neurobiology and Integrated Physiology of the University of Pavia, led by Professor Paola Rossi, in collaboration with Dr. Federico Brandalise of the Center for Learning and Memory of the University of Austin in Texas, is busy with the study of memory. Starting from the cells of central nervous system, neurons, it was possible to understanding the behavior of the animal and, in particular, the study of cognitive memory-related performance.

The cellular bases of learning and memory phenomena have been studiedin situ in hippocampus and cerebellum neuronal networks. Memory in neuronal circuits is expressed through plastic changes of neuronal communication, that cause a more efficient transmission of recollection’s information in the neuronal network. In parallel, the tuning of the test of memory on experimental animals made it possible to evaluate the effects of plastic changes, induced in the neuronal network, on the cognitive ability of the animal.
Collaboration with Laboratories of Prof. Rosanna Nano and Prof. EnricaCapelli’s will allow us to expand the research already started to study the details of cellular mechanisms involved in memory processes, focusing the interest on molecular and epigenetic changes, that are able to influence our ability to remember. In particular, the two research strands, which will be undertaken, will be, on the one hand, the study of growth factors effects on memory, such as NGF (nerve growth factor) and BDNF (brain derived growth factor) and, on the other, the study of changes that affect our phenotype without altering our genotype. In the latter case, thanks to epigenetic, the effects of the environment on gene expression of genes related to memory will be studied.

The peculiarity of an integrated approach and the possibility of studying memory at the genetic, cellular, neural and behavioral levels make this research particularly promising both in terms of “healthy aging” and in the potential for relapsing neurodegenerative pathologies such as Alzheimer’s, Parkinson’s, and dementia.

This crowdfunding will allow us to study memory, aging and cognitive functions in mouse, without the use of invasive methods and using the latest generation technologies. We will also investigate how two diets, one high in sugar and one antioxidant, affect cognitive function and aging.


LINK

http://www.unipv.eu/site/home.html
http://dbb.unipv.it
http://genmic.unipv.eu/site/home/didattica/scheda80004292.html

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Goals

17.000 €

Scholarship and materials

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Team

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Paola Rossi

Prof. | Founder

Paola Rossi

Prof. | Founder
Associate Professor, PhD in Physiological Sciences, Bio/09, General Physiology, University of Pavia Complete CV  
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Rosanna Nano

Prof.

Rosanna Nano

Prof.
Full Professor at the Department of Biology and Biotecnology “L. Spallanzani”, University of Pavia Complete CV
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Enrica Capelli

Prof.

Enrica Capelli

Prof.
Senior researcher, Department of Earth and Environmental Sciences, University of Pavia Complete CV
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Alessandra Occhinegro

Dott.

Alessandra Occhinegro

Dott.
Intern at university’s laboratory of “Integrated system’s physiology” and candidate for a Master’s degree in “Neurobiology” at University of Pavia Complete CV
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Daniela Ratto

Dott.

Daniela Ratto

Dott.
Scholarship in Neurobiology and Integrated Physiology Laboratory, University of Pavia Complete CV
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Carmelisa Lombardo

Dott.

Carmelisa Lombardo

Dott.
Research Collaborator, Laboratory of Immunology and Genetic Analysis, Dipartimento di Scienze della Terra e dell’Ambiente and Centre for Health Technologies (CHT), University of Pavia Complete CV
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Giuseppe Francesco Damiano Lupo

Dott.

Giuseppe Francesco Damiano Lupo

Dott.
Scholarship holder at Department of Earth and Environmental Sciences (Laboratory of Immunology and genetic analysis), University of Pavia Complete CV
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Giulia Schilardi

Student

Giulia Schilardi

Student
Student, University of Pavia Complete CV
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Eleonora Centonze

Student

Eleonora Centonze

Student
Student, University of Pavia Complete CV
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Silvia Cazzanelli

Student

Silvia Cazzanelli

Student
Student, University of Pavia Complete CV

Backers

  1. A.V.D. REFORM S.r.l.
  2. Carla Perotti
  3. Evento Prof. Barili
  4. Contributo Inner Wheel
  5. Rotary Club Siziano
  6. Anna Tedeschi
  7. Evento concerto Scuola Cairoli
  8. Evento "Sfilata Aula '400"
  9. Evento "Cena dolce salato"
  10. Conferenza Albenga del 12 gennaio 2018
  11. Fondazione comunitaria della Provincia di Pavia
  12. Anonymous
  13. KIWANIS Pavia
  14. A ricordo di Ettore Bonfatti Sabbioni Pittore e incisore
  15. Accademia portieri
  16. Conferenza accademia dei portieri Zdravkova/Fozzi
  17. Alessandro Antonio Rossotto
  18. Accademia portieri di calcio
  19. Loretta Ghilardi
  20. Centro Fitness time
  21. Bromatech SRL
  22. Anonymous
  23. Marcello Romeo
  24. Alberto Petrucco Liliana Petrucco
  25. Centro Sociologico italiano
  26. Istituto per lo studio e la cura del diabete
  27. Agenzia immobiliare il Castello
  28. Emanuela Viglino
  29. Antonio Veronesi
  30. Raffaele Di Francia
  31. Compagnia Europea Alimenti
  32. Veronica Gugliotta
  33. Cena collegio Cairoli organizzata da: R.L.AKH-EN-ATON n. 1132 PAVIA
  34. Evento "Presentazione del libro di M. Berretta"
  35. Evento "Aperitivo con il cervellone"
  36. Cristina Rossi
  37. Anonymous
  38. Anonymous
  39. METEDA SRL
  40. GUNA S.P.A.
  41. Anonymous
  42. NAMED S.P.A.
  43. A.V.D. REFORM SRL
  44. Evento "La Bodeguita" 26-5-17
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