The project

Myeloproliferative neoplasms (polycythemia vera, essential thrombocythemia, primary myelofibrosis) are caused by an alteration of the hematopoietic stem cell in the bone marrow, namely the cell responsible for the production of red blood cells, white blood cells, platelets.

In myeloproliferative neoplasms, the uncontrolled proliferation of the hematopoietic stem cell causes an abnormal increase of these mature cells in the peripheral blood (mainly red blood cells in polycythemia vera, platelets in essential thrombocythemia, white blood cells in primary myelofibrosis).

MPN are chronic disorders, with a slow and progressive course. The increased number of red blood cells, white blood cells or platelets makes blood less fluid and can cause an increased risk of obstruction of veins or arteries (thrombosis). In a small percentage of patients, the disease can evolve to secondary acute myeloid leukemia with a poor prognosis.

Before 2005 the molecular basis of myeloproliferative neoplasms was unknown. Today we know that 90% of patients has a mutation in one of three genes: JAK2, CALR, MPL. In the remaining 10% of patients the molecular basis is unknown.

The discovery of mutations has stimulated the identification of targeted drugs such as the JAK inhibitors, able to selectively damage the mutated cells. Not all patients obtain a complete response with JAK inhibitors.

The project is aimed to characterize the impact of the three mutations on the clinical phenotype of the disease (Pavia), to identify the mutation/s responsible for the remaining 10% of patients with unknown pathogenesis (Vienna), to identify the molecular mechanisms responsible for resistance to JAK inhibitors (Boston).


Link:
www.ematologia-pavia.it
www.aeponlus.it/index3.php

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Goals

First goal: 12.500 euro

Contract for 6 months for a young researcher

First goal: 25.000 euro

Extension of the research contract for other 6 months

Sponsor

Rogledi

Rogledi Pianoforti Pavia

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Rewards

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Donation of 50 €

Guided tour to the museum of the University of Pavia

Donation of 500 €

For Companies who will sponsor the crowdfunding, the company logo will appear on the official website

Donation of 1000 €

Acknowledgments in the scientific publication

Team

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Elisa Rumi

| Founder

Elisa Rumi

| Founder
Professor of Hematology, Department of Molecular Medicine, University of Pavia, Italy Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo Pavia, Italy
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Ilaria Casetti

Ilaria Casetti

PhD student, Department of Molecular Medicine, University of Pavia, Italy
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Chiara Cavalloni

Chiara Cavalloni

Research fellow, Department of Molecular Medicine, University of Pavia, Italy
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Michele Ciboddo

Michele Ciboddo

Resident in the School of Specialization of Hematology, University of Pavia, Italy
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Daniela Pietra

Daniela Pietra

PhD, Biologist, Fondazione IRCCS Policlinico San Matteo Pavia, Italy
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Elisa Roncoroni

Elisa Roncoroni

Clinical researcher at the Department of Hematology Oncology
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Backers

  1. Matteo Provasi
  2. AVIS Comune di Stradella
  3. Paola Coscia
  4. Alberto Waldner Anna Maria Andreis
  5. Luciana Marcante Marco Facchini
  6. Isabella Montesano
  7. Luciana Marcante
  8. Santino Mantarro
  9. Giovanni Zanetti
  10. angela faverio
  11. Anonymous
  12. Raffaella Di Carlo
  13. Narcisio Venardelli
  14. Paolo Boniardi Ivana Eusebio
  15. Enrico Calvi Rosella Pelanda In memoria di Angelo Boffelli
  16. Rizqallah Raedah
  17. evento distribuzione riso cascine costa
  18. Francesco D'Alessio
  19. Alba Annalisa Raimondo
  20. Carla Oldani Raffaella Grandi
  21. Giovanna Sciancalepore
  22. Danilo Suman
  23. Rosa Bianchi
  24. Angela Nunzia Ricci
  25. quarta serata touring club italiano
  26. Fabrizio Papi Barbara Leonetti
  27. Daniela Lina Paganoni
  28. terza serata touring club italiano
  29. Paolo e Chiara Danelli
  30. seconda serata touring club italiano
  31. Debbie Kafka
  32. Maurizio Provini
  33. Antonella Lazzaroni
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  44. Pier Quinto Casetti
  45. Annalisa Zanni
  46. Giuseppina Fanzini
  47. Mirella Trotti-Rech
  48. Leonardo Sirsi
  49. Carlo Carpanelli
  50. Maurizio Invernici
  51. Elena Rossin
  52. luigi agnelli
  53. viviana ciardi
  54. Anonymous
  55. Bar Vittoria Stradella
  56. AVIS Comunale di Stradella
  57. olga traversa
  58. angela faverio
  59. Anonimo
  60. Anonimo
  61. Anonimo
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  64. Chiara Generali
  65. Andrea Bertarini
  66. Chiara Giacon
  67. Chiara Poselle Bonaventura
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Contribute
  • Donazione minima

  • Maglietta Universitiamo

  • Maglietta + shopper Universitiamo

  • Visita gratuita al museo per la storia dell'Università di Pavia

  • Logo nella sezione sponsor della piattaforma Universitiamo

  • Ringraziamento su rivista scientifica

Would you like to donate by bank transfer? click here


Would you like to donate more then 1600€ click here