The project

Myeloproliferative neoplasms (polycythemia vera, essential thrombocythemia, primary myelofibrosis) are caused by an alteration of the hematopoietic stem cell in the bone marrow, namely the cell responsible for the production of red blood cells, white blood cells, platelets.

In myeloproliferative neoplasms, the uncontrolled proliferation of the hematopoietic stem cell causes an abnormal increase of these mature cells in the peripheral blood (mainly red blood cells in polycythemia vera, platelets in essential thrombocythemia, white blood cells in primary myelofibrosis).

MPN are chronic disorders, with a slow and progressive course. The increased number of red blood cells, white blood cells or platelets makes blood less fluid and can cause an increased risk of obstruction of veins or arteries (thrombosis). In a small percentage of patients, the disease can evolve to secondary acute myeloid leukemia with a poor prognosis.

Before 2005 the molecular basis of myeloproliferative neoplasms was unknown. Today we know that 90% of patients has a mutation in one of three genes: JAK2, CALR, MPL. In the remaining 10% of patients the molecular basis is unknown.

The discovery of mutations has stimulated the identification of targeted drugs such as the JAK inhibitors, able to selectively damage the mutated cells. Not all patients obtain a complete response with JAK inhibitors.

The project is aimed to characterize the impact of the three mutations on the clinical phenotype of the disease (Pavia), to identify the mutation/s responsible for the remaining 10% of patients with unknown pathogenesis (Vienna), to identify the molecular mechanisms responsible for resistance to JAK inhibitors (Boston).


Link:
www.ematologia-pavia.it
www.aeponlus.it/index3.php

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Goals

First goal: 12.500 euro

Contract for 6 months for a young researcher

First goal: 25.000 euro

Extension of the research contract for other 6 months

Sponsor

Rogledi

Rogledi Pianoforti Pavia

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Team

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Elisa Rumi

| Founder

Elisa Rumi

| Founder
Professor of Hematology, Department of Molecular Medicine, University of Pavia, Italy Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo Pavia, Italy
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Ilaria Casetti

Ilaria Casetti

PhD student, Department of Molecular Medicine, University of Pavia, Italy
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Chiara Cavalloni

Chiara Cavalloni

Research fellow, Department of Molecular Medicine, University of Pavia, Italy
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Michele Ciboddo

Michele Ciboddo

Resident in the School of Specialization of Hematology, University of Pavia, Italy
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Daniela Pietra

Daniela Pietra

PhD, Biologist, Fondazione IRCCS Policlinico San Matteo Pavia, Italy
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Elisa Roncoroni

Elisa Roncoroni

Clinical researcher at the Department of Hematology Oncology
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Backers

  1. Nir Shoshani
  2. evento lotteria (quarta raccolta)
  3. Nir Shoshani
  4. Costanzo Andrea Panto' Carmela
  5. evento lotteria (terza raccolta)
  6. evento lotteria (seconda raccolta)
  7. Anonymous
  8. KATIA DANELLI
  9. evento lotteria
  10. AVIS Comune di Stradella
  11. Alberto Waldner Anna Maria Andreis
  12. Paola Coscia
  13. Luciana Marcante Marco Facchini
  14. Isabella Montesano
  15. Luciana Marcante
  16. Santino Mantarro
  17. Giovanni Zanetti
  18. angela faverio
  19. Anonymous
  20. Raffaella Di Carlo
  21. Narcisio Venardelli
  22. Paolo Boniardi Ivana Eusebio
  23. Enrico Calvi Rosella Pelanda In memoria di Angelo Boffelli
  24. Rizqallah Raedah
  25. evento distribuzione riso cascine costa
  26. Francesco D'Alessio
  27. Alba Annalisa Raimondo
  28. Carla Oldani Raffaella Grandi
  29. Giovanna Sciancalepore
  30. Danilo Suman
  31. Angela Nunzia Ricci
  32. Rosa Bianchi
  33. quarta serata touring club italiano
  34. Daniela Lina Paganoni
  35. Fabrizio Papi Barbara Leonetti
  36. terza serata touring club italiano
  37. Paolo e Chiara Danelli
  38. seconda serata touring club italiano
  39. Antonella Lazzaroni
  40. Maurizio Provini
  41. COMPAGNIE ITTICHE RIUNITE
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  51. Carlo Carpanelli
  52. Maurizio Invernici
  53. Elena Rossin
  54. Pier Quinto Casetti
  55. Annalisa Zanni
  56. Giuseppina Fanzini
  57. Mirella Trotti-Rech
  58. Leonardo Sirsi
  59. luigi agnelli
  60. viviana ciardi
  61. Anonymous
  62. Bar Vittoria Stradella
  63. AVIS Comunale di Stradella
  64. olga traversa
  65. angela faverio
  66. Anonimo
  67. Anonimo
  68. Anonimo
  69. Anonimo
  70. Anonimo
  71. Chiara Generali
  72. Andrea Bertarini
  73. Chiara Giacon
  74. Chiara Poselle Bonaventura
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Contribute
  • Donazione minima

  • Maglietta Universitiamo

  • Maglietta + shopper Universitiamo

  • Visita gratuita al museo per la storia dell'Università di Pavia

  • Logo nella sezione sponsor della piattaforma Universitiamo

  • Ringraziamento su rivista scientifica

Would you like to donate by bank transfer? click here


Would you like to donate more then 1600€ click here