The project

Myeloproliferative neoplasms (polycythemia vera, essential thrombocythemia, primary myelofibrosis) are caused by an alteration of the hematopoietic stem cell in the bone marrow, namely the cell responsible for the production of red blood cells, white blood cells, platelets.

In myeloproliferative neoplasms, the uncontrolled proliferation of the hematopoietic stem cell causes an abnormal increase of these mature cells in the peripheral blood (mainly red blood cells in polycythemia vera, platelets in essential thrombocythemia, white blood cells in primary myelofibrosis).

MPN are chronic disorders, with a slow and progressive course. The increased number of red blood cells, white blood cells or platelets makes blood less fluid and can cause an increased risk of obstruction of veins or arteries (thrombosis). In a small percentage of patients, the disease can evolve to secondary acute myeloid leukemia with a poor prognosis.

Before 2005 the molecular basis of myeloproliferative neoplasms was unknown. Today we know that 90% of patients has a mutation in one of three genes: JAK2, CALR, MPL. In the remaining 10% of patients the molecular basis is unknown.

The discovery of mutations has stimulated the identification of targeted drugs such as the JAK inhibitors, able to selectively damage the mutated cells. Not all patients obtain a complete response with JAK inhibitors.

The project is aimed to characterize the impact of the three mutations on the clinical phenotype of the disease (Pavia), to identify the mutation/s responsible for the remaining 10% of patients with unknown pathogenesis (Vienna), to identify the molecular mechanisms responsible for resistance to JAK inhibitors (Boston).


Link:
www.ematologia-pavia.it
www.aeponlus.it/index3.php

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Goals

First goal: 12.500 euro

Contract for 6 months for a young researcher

First goal: 25.000 euro

Extension of the research contract for other 6 months

Sponsor

Rogledi

Rogledi Pianoforti Pavia

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Team

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Elisa Rumi

| Founder

Elisa Rumi

| Founder
Professor of Hematology, Department of Molecular Medicine, University of Pavia, Italy Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo Pavia, Italy
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Ilaria Casetti

Ilaria Casetti

PhD student, Department of Molecular Medicine, University of Pavia, Italy
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Chiara Cavalloni

Chiara Cavalloni

Research fellow, Department of Molecular Medicine, University of Pavia, Italy
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Michele Ciboddo

Michele Ciboddo

Resident in the School of Specialization of Hematology, University of Pavia, Italy
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Daniela Pietra

Daniela Pietra

PhD, Biologist, Fondazione IRCCS Policlinico San Matteo Pavia, Italy
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Elisa Roncoroni

Elisa Roncoroni

Clinical researcher at the Department of Hematology Oncology
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Backers

  1. Russo Carmine Russo Fortunato
  2. Nir Shoshani
  3. evento lotteria (quarta raccolta)
  4. Nir Shoshani
  5. Costanzo Andrea Panto' Carmela
  6. evento lotteria (terza raccolta)
  7. evento lotteria (seconda raccolta)
  8. Anonymous
  9. KATIA DANELLI
  10. evento lotteria
  11. AVIS Comune di Stradella
  12. Alberto Waldner Anna Maria Andreis
  13. Paola Coscia
  14. Luciana Marcante Marco Facchini
  15. Isabella Montesano
  16. Luciana Marcante
  17. Santino Mantarro
  18. Giovanni Zanetti
  19. angela faverio
  20. Anonymous
  21. Raffaella Di Carlo
  22. Narcisio Venardelli
  23. Paolo Boniardi Ivana Eusebio
  24. Enrico Calvi Rosella Pelanda In memoria di Angelo Boffelli
  25. Rizqallah Raedah
  26. evento distribuzione riso cascine costa
  27. Francesco D'Alessio
  28. Alba Annalisa Raimondo
  29. Carla Oldani Raffaella Grandi
  30. Giovanna Sciancalepore
  31. Danilo Suman
  32. Angela Nunzia Ricci
  33. Rosa Bianchi
  34. quarta serata touring club italiano
  35. Daniela Lina Paganoni
  36. Fabrizio Papi Barbara Leonetti
  37. terza serata touring club italiano
  38. Paolo e Chiara Danelli
  39. seconda serata touring club italiano
  40. Antonella Lazzaroni
  41. Maurizio Provini
  42. COMPAGNIE ITTICHE RIUNITE
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  52. Carlo Carpanelli
  53. Maurizio Invernici
  54. Elena Rossin
  55. Pier Quinto Casetti
  56. Annalisa Zanni
  57. Giuseppina Fanzini
  58. Mirella Trotti-Rech
  59. Leonardo Sirsi
  60. luigi agnelli
  61. viviana ciardi
  62. Anonymous
  63. Bar Vittoria Stradella
  64. AVIS Comunale di Stradella
  65. olga traversa
  66. angela faverio
  67. Anonimo
  68. Anonimo
  69. Anonimo
  70. Anonimo
  71. Anonimo
  72. Chiara Generali
  73. Andrea Bertarini
  74. Chiara Giacon
  75. Chiara Poselle Bonaventura
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Contribute
  • Donazione minima

  • Maglietta Universitiamo

  • Maglietta + shopper Universitiamo

  • Visita gratuita al museo per la storia dell'Università di Pavia

  • Logo nella sezione sponsor della piattaforma Universitiamo

  • Ringraziamento su rivista scientifica

Would you like to donate by bank transfer? click here


Would you like to donate more then 1600€ click here