The project

Myeloproliferative neoplasms (polycythemia vera, essential thrombocythemia, primary myelofibrosis) are caused by an alteration of the hematopoietic stem cell in the bone marrow, namely the cell responsible for the production of red blood cells, white blood cells, platelets.

In myeloproliferative neoplasms, the uncontrolled proliferation of the hematopoietic stem cell causes an abnormal increase of these mature cells in the peripheral blood (mainly red blood cells in polycythemia vera, platelets in essential thrombocythemia, white blood cells in primary myelofibrosis).

MPN are chronic disorders, with a slow and progressive course. The increased number of red blood cells, white blood cells or platelets makes blood less fluid and can cause an increased risk of obstruction of veins or arteries (thrombosis). In a small percentage of patients, the disease can evolve to secondary acute myeloid leukemia with a poor prognosis.

Before 2005 the molecular basis of myeloproliferative neoplasms was unknown. Today we know that 90% of patients has a mutation in one of three genes: JAK2, CALR, MPL. In the remaining 10% of patients the molecular basis is unknown.

The discovery of mutations has stimulated the identification of targeted drugs such as the JAK inhibitors, able to selectively damage the mutated cells. Not all patients obtain a complete response with JAK inhibitors.

The project is aimed to characterize the impact of the three mutations on the clinical phenotype of the disease (Pavia), to identify the mutation/s responsible for the remaining 10% of patients with unknown pathogenesis (Vienna), to identify the molecular mechanisms responsible for resistance to JAK inhibitors (Boston).


Link:
www.ematologia-pavia.it
www.aeponlus.it/index3.php

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Goals

First goal: 12.500 euro

Contract for 6 months for a young researcher

First goal: 25.000 euro

Extension of the research contract for other 6 months

Sponsor

Rogledi

Rogledi Pianoforti Pavia

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Team

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Elisa Rumi

| Founder

Elisa Rumi

| Founder
Professor of Hematology, Department of Molecular Medicine, University of Pavia, Italy Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo Pavia, Italy
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Ilaria Casetti

Ilaria Casetti

PhD student, Department of Molecular Medicine, University of Pavia, Italy
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Chiara Cavalloni

Chiara Cavalloni

Research fellow, Department of Molecular Medicine, University of Pavia, Italy
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Michele Ciboddo

Michele Ciboddo

Resident in the School of Specialization of Hematology, University of Pavia, Italy
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Daniela Pietra

Daniela Pietra

PhD, Biologist, Fondazione IRCCS Policlinico San Matteo Pavia, Italy
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Elisa Roncoroni

Elisa Roncoroni

Clinical researcher at the Department of Hematology Oncology
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Backers

  1. LIONS CLUB STRADELLA BRONI
  2. Russo Carmine Russo Fortunato
  3. Nir Shoshani
  4. evento lotteria (quarta raccolta)
  5. Nir Shoshani
  6. Costanzo Andrea Panto' Carmela
  7. evento lotteria (terza raccolta)
  8. evento lotteria (seconda raccolta)
  9. Anonymous
  10. KATIA DANELLI
  11. evento lotteria
  12. AVIS Comune di Stradella
  13. Alberto Waldner Anna Maria Andreis
  14. Paola Coscia
  15. Luciana Marcante Marco Facchini
  16. Isabella Montesano
  17. Luciana Marcante
  18. Santino Mantarro
  19. Giovanni Zanetti
  20. angela faverio
  21. Anonymous
  22. Raffaella Di Carlo
  23. Narcisio Venardelli
  24. Paolo Boniardi Ivana Eusebio
  25. Enrico Calvi Rosella Pelanda In memoria di Angelo Boffelli
  26. Rizqallah Raedah
  27. evento distribuzione riso cascine costa
  28. Francesco D'Alessio
  29. Alba Annalisa Raimondo
  30. Carla Oldani Raffaella Grandi
  31. Giovanna Sciancalepore
  32. Danilo Suman
  33. Angela Nunzia Ricci
  34. Rosa Bianchi
  35. quarta serata touring club italiano
  36. Daniela Lina Paganoni
  37. Fabrizio Papi Barbara Leonetti
  38. terza serata touring club italiano
  39. Paolo e Chiara Danelli
  40. seconda serata touring club italiano
  41. Antonella Lazzaroni
  42. Maurizio Provini
  43. COMPAGNIE ITTICHE RIUNITE
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  53. Carlo Carpanelli
  54. Maurizio Invernici
  55. Elena Rossin
  56. Pier Quinto Casetti
  57. Annalisa Zanni
  58. Giuseppina Fanzini
  59. Mirella Trotti-Rech
  60. Leonardo Sirsi
  61. luigi agnelli
  62. viviana ciardi
  63. Anonymous
  64. Bar Vittoria Stradella
  65. AVIS Comunale di Stradella
  66. olga traversa
  67. angela faverio
  68. Anonimo
  69. Anonimo
  70. Anonimo
  71. Anonimo
  72. Anonimo
  73. Chiara Generali
  74. Andrea Bertarini
  75. Chiara Giacon
  76. Chiara Poselle Bonaventura
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Contribute
  • Donazione minima

  • Maglietta Universitiamo

  • Maglietta + shopper Universitiamo

  • Visita gratuita al museo per la storia dell'Università di Pavia

  • Logo nella sezione sponsor della piattaforma Universitiamo

  • Ringraziamento su rivista scientifica

Would you like to donate by bank transfer? click here


Would you like to donate more then 1600€ click here