Funding Successful. This project reached its goal before 28/06/2016.

The project
Wednesday March 2nd, 2016

Tinnitus (i.e. the perception of phantom sounds, such as ringing or buzzing) is a quite common pathology: in Europe, about 70 million people suffer from it, and for 7 million people tinnitus is a debilitating condition. Although severe tinnitus is associated with disturbances of attention, sleep and mood, such as anxiety and depression, this pathology is often underestimated, also given the difficulties in diagnosing with certainty its causes and severity. In fact, patients affected by severe tinnitus often have a long and frustrating clinical history.

To date, therapies employed for this pathology display highly variable effects, and this has led scientists and clinicians to view tinnitus as a symptom associated to several possible pathologies, which only share phenomena of aberrant neural plasticity. The european project COST-TINNET (of which the founder of this project is part), currently ongoing, is actually aimed at characterizing tinnitus heterogeneity and at defining guidelines for tinnitus diagnosis and treatment.

In our lab we are studying the neural plasticity involved in tinnitus onset, and in particular the involvement of microglial cells, main players in neuroinflammation, bridging nervous and immune systems. Preliminary studies from our lab and from other international labs have shown that, in presence of tinnitus, microglial cells activate in several stations of the auditory system (e.g. cochlear nuclei).

Since microglia appears involved in several nervous system pathologies, in the last few years several drugs modulating its action have been made available, as well as some minimally invasive tests allowing in vivo observation of several of its activities. However, none of these have been explored in the context of tinnitus.

Aim of the present project is to observe the correlations between tinnitus and microglial response, in order to:

  • Categorize possibile tinnitus subtypes as a function of microglial response variability and localization in the nervous system;
  • Identify, especially among available drugs targeted at neuroinflamation, possible new pharmacological therapies for tinnitus;
  • Ascertain whether the microglial activation observed in association to tinnitus may be used to develop a diagnostic test to be used in clinical routine.

Your donation will contribute to understand tinnitus, and to provide new tools for its diagnosis and cure. Moreover, if you help spreading this crowdfunding campaign, you will help raising public awareness of tinnitus, which although being quite common and of high social and economical impact, is still an overlooked “orphan disease” without adequate attention.

 

LINK

https://www.facebook.com/Silenzio-per-favore-1549757182005756/
https://twitter.com/search?q=%40silencetinnitus&src=typd
https://www.facebook.com/groups/1475291859375234/
http://tinnet.tinnitusresearch.net/
http://www.tinnitus.org.uk/
http://tinnitusresearch.org/

Goals

Raised funds will be used for instrumentation for lab research and for research fellowships.

We have 3 sequential targets:

Initial target: 20.000 €

equipment for 3DISCO microscopy

Middle target: 35.000 €

1 year research fellowship

Final target: 50.000 €

2 years research fellowship

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Rewards

 

DONATION € 20,00

Logo keyholder

DONATION € 50,00

Deluxe logo keyholder

DONATION € 100,00

3d-printed microglial cell or logo t-shirt

DONATION € 500,00

Acknowledgement on scientific paper and manuscript copy

Team

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Paola Perin

Prof. | Founder

Paola Perin

Prof. | Founder
Assistant Professor of Physiology - Department of Brain and Behavioural Sciences. Complete CV
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Roberto Pizzala

Prof.

Roberto Pizzala

Prof.
Associate Professor of General Pathology - Department of Molecular Medicine. Complete CV
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Chiara Milanese

Prof.

Chiara Milanese

Prof.
Associate Professor of Physical Chemistry - Department of Chemistry. Complete CV
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Alessandro Venturino

Dott.

Alessandro Venturino

Dott.
Research Fellow at the Institute for Science and Technology Austria. Complete CV
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Adriano Oda

Dott.

Adriano Oda

Dott.
Neurobiology MS. Complete CV
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Alessia Capetta

Dott.

Alessia Capetta

Dott.
Neurobiology MS. Complete CV

Backers

  1. Gianni Sanna
  2. Anonymous
  3. Intesa San Paolo San Paolo
  4. Flavia Posabella
  5. Anonymous
  6. Massimo
  7. Anonymous
  8. Giuseppe Gullà
  9. Caruso Serafino San Paolo
  10. Carlo Zia
  11. Giovanni Russo
  12. PAOLA GAROFALO
  13. Anonymous
  14. Anonymous
  15. Curti Alberto Curti Elvio San Paolo
  16. Gabriele Macchi San Paolo
  17. Associazione Italiana Tinnitus San Paolo
  18. MR
  19. Maria Vittoria Bucco
  20. MR g
  21. Associazione Italiana Tinnitus San Paolo
  22. Anonymous
  23. Comunità di Castiglione della Pescaia San Paolo
  24. franco spedale
  25. Dario Rondini
  26. Renato Sacco
  27. luca pasini
  28. gabriele macchi
  29. Associazione Italiana Tinnitus San Paolo
  30. Anonymous
  31. Cavalieri della Musica c/o I.C. Cavalieri - Milano
  32. Patrizia Zandona San Paolo
  33. Carlo Bigaran
  34. Anonymous
  35. Orlando Tricerri
  36. Gianluca Perilli
  37. Alessio Rocchi
  38. ISTITUTO COMPRENSIVO CAVALIERI - MILANO
  39. Fondazione Costa Onlus San Paolo
  40. Anonymous
  41. Rossi Rosetta San Paolo
  42. Hugo de Jonge
  43. Teresa callegaro
  44. Guido Bortolan
  45. cosimo damiano matarrese
  46. Francesco Tecca San Paolo
  47. Renzo Signorini
  48. SAMUEL Corazza
  49. Adriano Cariati
  50. Daniele Dei
  51. Michele Cillis
  52. Chiara Stella Zonghi
  53. Anonymous
  54. davide sponziello
  55. Ivan Ballarin
  56. Manzi Carmela San Paolo
  57. Anonymous
  58. Tommaso Armellini
  59. piero boni
  60. Alberto Montebello
  61. Anita Perin
  62. Marzia Ravasio
  63. Anonymous
  64. gabriele macchi
  65. stefano
  66. Paola Dal Zotto
  67. gabriele macchi
  68. Romano Annalisa Maria Rita Tel
  69. Michele Gobbi
  70. Anonymous
  71. Anonymous
  72. Anonymous
  73. Anonymous
  74. stefania cavalieri
  75. Giovanni Sanna
  76. simone amato
  77. Clara Maria Salvarezza San Paolo
  78. Pietro Molina
  79. Anonymous
  80. gabriele macchi
  81. simone amato
  82. Carmela Manzi San Paolo
  83. Macchi Gabriele San Paolo
  84. Stillitano Carmela San Paolo
  85. Zia Carlo San Paolo
  86. Macchi Gabriele San Paolo
  87. Miceli Salvatore Andrea Raffae
  88. Anonymous
  89. Michele Pierangeli http://Tinnitushunt.com
  90. Marco Gasco
  91. Giambelluca Annalisa San Paolo
  92. De Antoni Giampietro San Paolo
  93. Capecchi Laura San Paolo
  94. Galbiati Betty Sabrina Van Win
  95. Luigi Rubino San Paolo
  96. Corvi Vanda San Paolo
  97. Pitardi Federica San Paolo
  98. Morandi Walter Pedroni Maria
  99. Carlo Zia
  100. stefania cavalieri
  101. Carlotta Fabiani
  102. alessandro alberti
  103. Giampietro De Antoni
  104. Sauro Mori
  105. Luigi Nautilli Celest. Montalti
  106. Francesco Lippi San Paolo
  107. Gianluca De Fraia San Paolo
  108. Amalia Giovenco San Paolo
  109. Gianluca Simonelli
  110. Adriano Cariati
  111. Angelo Puzzo
  112. Gualini Pierangelo San Paolo
  113. Lineattiva sas di Lusini Daniela San Paolo
  114. Rebecchi Rag. Antonella San Paolo
  115. Giacomo Trovesi Bergamaschi Ma.
  116. Raffaella Brandoli San Paolo
  117. Anonymous
  118. GIOVANNI NATOLI
  119. FAbio Vasques
  120. Flavia Posabella
  121. Dionisio Ferrari
  122. Stefano Lorini
  123. raffaele mariottini
  124. GIOVANNI NATOLI
  125. Simone Pagni
  126. giacomo artibani
  127. Lucia Mastromarino
  128. Angelo Riccardi
  129. Anonymous
  130. renzo boeche
  131. Alessandro Agati
  132. Anonymous
  133. Giuseppe Allosso
  134. Costantino Pallante
  135. Carlo Zia
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  • Minimum Donation

  • Logo keyholder

  • Deluxe logo keyholder

  • 3d-printed microglial cell or logo t-shirt

  • Acknowledgement on scientific paper and manuscript copy